用逐步回归方法探讨与鼻咽癌细胞间变有关的因素

A Correlation Study of Clinicopathologic Factors and Cell Anaplasia in Nasopharyngeal Carcinoma (NPC) by Stepwise Regression Analyses

摘要: 本文用逐步回归的方法对15项可能与鼻咽癌细胞间变有关的因素进行筛选。在F值为3时获得较优的回归方程，由该方程揭示了5项与癌细胞间变有关的因素。这些因素是癌间质中血管密度，癌生长范围，癌转移，癌WHO分型和癌巢内淋巴细胞浸润量。癌细胞间变与前4项是正相关，说明间变癌细胞形态幼稚，生长活跃，易于浸润与转移。而癌巢内淋巴细胞浸润量与细胞间变是反相关，说明淋巴细胞浸润作为机体局部免疫反应，阻止癌细胞发展与间变。又因间变与患者预后密切相关，因此应将估价癌细胞间变的指标充实鼻咽癌的组织学分型中，使组织学类型具有预后意义。

Abstract: The influence of 15 clinicopathological factors on NPC anaplasia is analyzed using stepwise regression model in this paper. The most correlated factors affecting NPC anaplasia are screened out under F level of 3. They are 1) the density of vascularization, 2) histologic type (WHO Ⅱ/ Ⅲ), 3) tumour metastasis, 4) the size of tumour (T1 -T4), and 5) the lymphocytic infiltration in nest. These five major factors are including in the regression equation. The mechanism and effects of the five factors on the anaplasia are analyzed in the paper.Therefore we suggest that modification or a new histologic classification with prognostic significance are needed.