Abstract: The distributions of the receptor of estrogen (ER) and progesterone (PR)within liver cancerous and their surrounding tissues were studied by the enzyme linked affinity histochemistry in 41 cases of SHCC (male 35 cases, female 6 cases)which were followed up for years. The results showed that the staining reaction of ER and PR were weaker in cancerous tissues than their surronding liver tissue (P0. 01). There is no relationship between the positive rate and the different degree of carcinoma, but the positive rate of ER and PR were connected with the survival time. The positive rate of ER and PR is higher in the group with longer survival time. The results provide the basic theory for the probing into the therapy methods of HCC with anti-Hormone in some way.