P<sub>53</sub>蛋白在耐药的非小细胞肺癌的表达

P₅₃蛋白在耐药的非小细胞肺癌的表达

摘要: 突变型P₅₃蛋白在114例肺癌中阳性率为54.4%,其中腺癌为53.6%、鳞癌为57.1%、腺鳞混合型为50%.114例肺癌标本同时做丝裂霉素、阿霉素、顺铂和长春新碱的体外药敏试验。在抗癌药物耐药性和P53蛋白表达的关系中，P53蛋白阳性表达的肺癌细胞对四种抗癌药全不敏感或单药敏感者占78.8%,有统计学意义（P<0.05）.P₅₃蛋白阴性表达的肺癌细胞对四种抗癌药的敏感性无明显相关。提示突变型P53蛋白可作为肺癌的耐药标志物。

Abstract: One hundred and fourteen human lung carcinomas were analyzed for presence of P₅₃ by means of immunohistochemistry. Sixty two (54. 4%) out of 114 human lung carcinomas expressed P₅₃. The expression of P₅₃ was compared with the results of drugsensitivity tested in vitro. A significant relationship between overexpression of P₅₃ and resistant of DDP, ADM, VCR, MMC was found (P0.05). The mutant P53 gene protein may be a resistant marker for non-small-cell-lung-cancer.