胃粘膜组织中CEA含量的研究及其临床意义探讨

Study on CEA Content of Gastric Mucosa and It's Clinic Significant

摘要: 我们应用ABC免疫组织化学技术对306例活检的胃粘膜组织进行了CEA含量的测定，结果显示：非萎缩性，萎缩性胃粘膜及胃癌组织中CEA检出阳性率分别是77.22%,86.47%,94.68%.在非萎缩性胃粘膜，萎缩性胃粘膜及胃癌组织中都有一定的CEA阳性显示率。CEA对定性诊断意义不大，但在阳性强度表达上有明显差别（P<0.01）,以胃癌明显。CEA阳性强度等级相关分析也显示CEA含量与胃癌及萎缩性胃炎病变程度是极明显的正相关（R>0.7）.CEA的测定对监测萎缩性胃炎的预后有一定价值。

Abstract: Abstract We determinated CEA content from the gastric mucosa of 306 patients who had gastric disease by immunohistochemical analysis. The CEA positive rate were 77. 22% in non-atrophic gastritis, 86. 47% in atrophic gastritisand 94. 68% in gastric cancer. Which meaning of diagnosis wasn't valuable. But the rank colleration analysis was strongly significance. The CEA content was positively correlated with the lesion degress of atrophic gastritis or gastric cancer (R 0. 7).From these results we conclue that determination of CEA content from gastric mucosa was valuable to monitoring atrophic gastritis prognosis.