急性白血病化疗药物敏感性ATP法的临床应用

Chemotherapeutic Sensitivity In Acute LeukemiaWith Bioluminescence measurement of ATP

摘要: 用ATP法对26例白血病病人进行体外药敏检查，观察其中18例急性白血病病人体外药敏与体内疗效关系。急性淋巴细胞白血病4例、急性非淋巴细胞白血病11例、慢性粒细胞白血病急性变3例。总符合率为83.3%，阳性符合率91.7%，阴性符合率66.7%.结果提示ATP法具有定量、短期、客观的临床应用价值。

Abstract: The chemosensitivity test were measured with ATP bioluminescence in 26leukemia patients.The relationship between chemosensitivity in viro and efficacyin vito was observed in 18 acute leukemia patients including 11 cases of acute nonlymphoblastic leukemia,4 cases of acute lymphoblastic leukemia and 3 cases ofchronic leukemia acute transformation.It was shown that the general,position andnegative coincident rates between chemosensitivity in vitro and efficacy in vivowere 83.3%, 91.7%and 66.7%' This assay has the merit being simple, sensitiveand quantitative.