Abstract: Combined chemotherapy using to plan of CA (E)P that is cyclophosphamid,adviamycin, cisplatin to treat non-small cell lung carcinoma was studied. In 125cases, male 111 cases, female 14 cases. The median age was 53. 5 years (17-72years). adeno-carcinoma 89 cases, squamous carcinoma 36 cases. The tatal effectine rate is 52. 0% (65/125). There were no significant difference between the adeno-carcinoma group and the squamous carcinoma group.Using Myocardial Engyme spectrum to exame the cardiac toxic seaction of Adviamycin. There were nosignificant difference in all cases between before and after chemotherapy. In 18 cases who has changes in ECG before chemotherapy, ECG changes were advions. Thedifference was statistitly significant (P0. 01). It is suggested that the patientwith the change of ECG using chemotherapy of adviamycin and epirabicin must becautions.