直肠癌ER／PE受体表达及预后关系的病理学分析

Pathological Analysis in the Relation with the Expression ER and PR and the Prognosis on the Rectal cancernoma

摘要: 本文应用石蜡切片免疫组化PAP法，回顾性观察了61例直肠中分化管状腺癌组织ER、PR表达情况。ER(+)/PR(+)为42.6%；ER(-)/PR(-)为57.4%。ER/PR的存在表明该癌组织具有了依赖性激素的特性。ER(+)/PR(+)者的中位生存期为4.5年，一、三、五年生存率为88.5%、53.9%、38.5%，均高于ER(-)/PR(-)者的生存率。　ER(-)/PR(-)者的中位生存期为2.4年，一、三、五年生存率为65.7%、42.8%、28.6%。表达阳性与阴性两者的生存期有明显差异(P<0.01)。检测ER/PR受体亦可做为判定预后的指标之一。本实验证实ER、PR表达与年龄、性别以及LNM之间无明显差异(P>0.05)。

Abstract: Expression of ER and PR in 61 cases with rectal middle differentiated adenocarcinoma were abserved by immunohistochemistry PAP method on paraffin section. The positive or negative rate of ER/PR were 42. 6% (26/61) or 57. 4% (35/61). The existance of ER/PR indicated that rectal cancernoma tissues possessedthe characteristic of depending upon sexhormone. The middle survival time of ER(+)/PR(+) or ER(-)/PR(-) was 4. 5-year time or 2. 5-year time. The 1,3, 5year survival rate of ER(+)/PR (+)(88. 5 %, 53. 9%, 38. 5%) were significantlyhigher than that of ER (-)/PR (-) (67. 5%, 42. 8%, 28. 6% ) (P0. 01). It isconcluded that the expression ER/PR for rectal cancer patients may be consideredas one of the indicators in the prognosis but in age, sex and LNM.