A<sub>g</sub>NOR检测对宫颈癌预后的意义

A_gNOR检测对宫颈癌预后的意义

摘要: 对73例随访10年以上的宫颈鳞癌进行A_gNOR计数分析，发现组织学D级的肿瘤细胞核内A_gNOR均值高于组织学Ⅰ级者为5.53± 1.47及4.40±1.34)。10年生存率亦有差异性，A_gNOR均值≥5者10年生存率为18%，而<5的10年生存率为46%(P<0.02)。结果表明，A_gNOR计数与宫颈鳞癌的组织学分级及临床预后有关。本文认为A_gNOR计数可作为一种肿瘤定量指标，对判定肿瘤恶性程度，预测宫颈癌预后具有一定参考价值。

Abstract: A_gNORs were analyzed with A_gNOR staining in 73 specimens of cervical squamous carcinoma. The results showed that A_gNORs of the specimens with Ⅱ histological grade were higher than that of grade Ⅰ, (5. 53±1. 47and, 4. 40±1. 34, respectively), and the patients whose A_gNORs were≥5. 0, have a lower 10-year survival rate than the patients whose A_gNORs were 5. 0, P0. 02. This indicated that there was a good correlation between A_gNORs and histolgical grade or prognosis of the cervical squamous carcinoma,A_gNORs could be regarded as a valuable index to judge the malignant grade and the prognosis of cervical squamous carcinoma.