肺癌患者外周血淋巴细胞微核、SCE和染色体畸变的研究

Study on the Micronucleus, Sister Chromatid Exchange (SCE) and Chtromosomal Aberration in lymphocytes of Patients with Lung Cancer

摘要: 本文分析观察14例肺癌患者和14例正常健康人外周血淋巴细胞的微核, SCE和染色体畸变。结果发现肺癌患者的微核率、SCE频率和染色体畸变率均高于正常对照组。经统计学分析表明两组之间差异显著, 认为染色体不稳定可能是肺癌发生的物质基础。

Abstract: In this paper, we analyze the changes of the frequencies of micronucleus, SCE and chromosomal aberration of 14 patients with lung cancer and 14normal persons.We found that the frequencies of micronucleus, SCE and chromosomal aberration in the patients with lung cancer were significantly higher than those in the normal persons (P＜0.01, P＜0.01, P＜0.05 ). We believe that chromosomal instability is the base of occurrence of lung cancer.