三种癌基因蛋白产物在结肠癌的表达及意义

Three roteins oncop cancer expression in colon and its significance

摘要: 用免疫组化方法检测4B例结肠良性病变和113例结肠癌中c－erbB－2、c－myc及P⁵³蛋白的表达。结果：三种癌基因蛋白产物在结肠癌中的表达显著高于结肠良性病变（P<0.01）。c－erbB－2、P⁵³蛋白表达与结肠癌淋巴结转移密切相关。P⁵³蛋白表达与结肠癌的分化程度有关。检测结肠癌组织中三种癌基因蛋白产物表达可作为结肠癌的诊断和判断预后的参考指标。

Abstract: The expression of c-erbB-2,c-myc and P53 protein in 42 benign colon disease tissues and 113 colon cancers was detected by immunohistochemical staining.The results showed that the three oncoproteins expression in the colon cancer was higher than in the bengin colon disease tissues(PGO.O1).In addition,there were signifi- cant correlation between that c-erbB-2 and P53 expression and node metastasis.The expression of P⁵³ was related to differentiation.It is suggested that the three onco-proteins can be used as markers for colon cancer diagnosis and prognosis.