大剂量醛氢叶酸合并氟脲嘧啶为主联合方案与FAM方案治疗晚期胃癌近期疗效分析

Analysisleucovorinof the short-term efficacy about high-doseand 5-Fu basedcombination coinadvanced gastricpared withFAM regimen in treatingcarcinoma

摘要: 用大剂量醛氢叶酸合并氟脲嘧咬为主联合方案与FAM方案分别治疗晚期胃癌30例，有效率分别为39．28%和43．33%，完全缓解率分别为10．71%和3．33%，P均＞0．05，两组消化道反应和骨髓抑制相似，FAM有2伊1出现心电图异常，而大剂量醛氢叶酸组无心电图异常，心脏毒性低于FAM组，我们认为大剂量醛氢叶酸合并氟脲嘧啶是治疗晚期胃癌的有效方案，尤其适用于有心脏病患者。

Abstract: Both 30 patients of advanced gastric carcinoma were treated to using high-dose leucovorin and based regimen and FAM regimen. The overall response rates were 39.28% and 43.330o respectively.The complete response rates were 10.71% and respectively .The gastrointestinal tract reaction and myelo-suppression were similar in both group.ECG abnormality was seen in patients in FAM group，but none in high-dose leucovorin group.Cardiac toxicities were less frequency in high-dose leucovorin group than in FAM group.The trial suggests that high-dose leucovorin and based regimen is effective for advanced gastric carcinoma and is especially suitable for patients with cardiac disorders.