西南地区原发性肝癌抗癌基因P<sup>53</sup>点突变的研究

西南地区原发性肝癌抗癌基因P⁵³点突变的研究

摘要: 本文采用PCR－RFLP技术对西南地区原发性肝细胞癌P⁵³基因第248和249位密码子点突变进行了研究。约17．4%的肝癌存在第249位密码子点突变。没有发现248位密码突变。本研究结果提示癌基因P⁵³点突变在该地区肝癌发病中起有一定作用；西南地区肝癌的发生可能有AFB1的参与。

Abstract: Mutation ofP⁵³ gene at codon were detected with PCR-RELP in primary hepastocellular carcinoma from Southwest China.The mutation of PS' gene at codon 249 were observed in 8 cases with positive of HBV serumal marker.However，no mutations at codon cases.The result suggest-ed that mutation at codon plays an importment role in HCC and AFB, may asso-ciate with a part of hepatocelluar carcinoma in Southwest China.