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AgNoR_s在胃镜刷检细胞中的表达与意义

高新平, 卢朝辉, 赵卫星, 张明彩, 和瑞芝

高新平, 卢朝辉, 赵卫星, 张明彩, 和瑞芝. AgNoR_s在胃镜刷检细胞中的表达与意义[J]. 肿瘤防治研究, 1997, 24(1): 24-26.
引用本文: 高新平, 卢朝辉, 赵卫星, 张明彩, 和瑞芝. AgNoR_s在胃镜刷检细胞中的表达与意义[J]. 肿瘤防治研究, 1997, 24(1): 24-26.
Gao Xinping, . Significance of agnors in gastroscope-brushing cytology[J]. Cancer Research on Prevention and Treatment, 1997, 24(1): 24-26.
Citation: Gao Xinping, . Significance of agnors in gastroscope-brushing cytology[J]. Cancer Research on Prevention and Treatment, 1997, 24(1): 24-26.

AgNoR_s在胃镜刷检细胞中的表达与意义

详细信息
  • 中图分类号: R730.4

Significance of agnors in gastroscope-brushing cytology

  • 摘要: 本文对照组织学应用银染技术对49例病人胃镜刷检细胞进行了核仁组成区相关嗜银蛋白定量研究。其中腺癌16例、鳞癌21例、非典型增生5例、慢性炎症7例。结果表明,随鳞状上皮病变级别增高,AgNoRs均数也逐级增高;腺癌细胞AgNoRs均数明显高于正常腺上皮细胞(P<0.05);正常细胞与癌细胞AgNoRs数目、形态、大小及分布都有显著差异。应用AgNoRs染色观察,使细胞学与组织学的诊断符合率由原来的75.51%提高到83.67%。表明AgNoRs在胃镜刷检细胞学中,同样是反映细胞增殖水平的敏感指标,尤其在大规模的细胞学普查中,可能有较大的实用价值。

     

    Abstract: Smers of gastroscope-brushing Cytology in 49 patients were examined with Ar-gyrophilie nucleolar organizer regionstain technique, the final diagnoses were based on the pareffin-embowered tissue sections, among which 16 adenocarcinomas, 21 squamous cell carcinomas 5 atypical dysplasias and 7 chronic inflammations. Rsscults showed that the mean number of AgNoR_s increased in proportion to the severity of lesion of the squamous cells; and more AgNoR_s in adenocareinoma cell than that in normal glandular epithelium cell were observed (P<0.05); Agnors in cancer cell are different from that in normal cells in amount, shage, size and disstri-bution within nucleus. The Conformance rate of cytology to histology increased from 75.51% to 83.67% by means of AgNoR_s determination. It suggested that Ag-NoR_s is a comparatively senstive index to reflect proliferative activity of cells in gas-troscope-brushing cytology. and may apply more practical utilization to general sur-vey of esophgeal and gastric diseases.

     

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出版历程
  • 刊出日期:  1997-02-04

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