儿童白血病医源性危险因素的病例对照研究

详细信息

A Case-Control Study on the iatrogenic risk factors of Childhood Leukemia

摘要: 为了探讨儿童白血病的病因，作者进行了1：1配对病例对照研究，结果表明儿童白血病的主要医源性危险因素是：儿童X线暴露（OR=4．53），儿童服用氯霉素（OR=3．60），儿童服用解热镇痛类药物（OR=1．93）。X线暴露与氯霉素、氯霉素与解热镇痛药对儿童白血病的发生有正的交互作用，人群归因危险度分析表明人群中71%的病例可归因于上述危险因素。
- 儿童白血病 /
- 医源性 /
- 危险因素 /
- 病例对照研究
Abstract: A 1:1 matched case-control study was condueted to investigate the etiology of childhood leukemia .It was found that there were three main iatrogenic risk factors: (1) Children's postnatal X-ray exposure, OR = 4.53; (2) Children took choram-phenicol,OR = 3.60; (3) Children took antipyretic/analgesic drugs, OR = 1.93. The analysis of the population attributable risk showed that 71% case of childhood leukemia can attributed to these three risk factors.The interaction among the risk factors was estimated, the result showed that there was a positive interaction be-tween the X-ray exposure and chorampphenicol on additive model.Based on the mul- tiplicative model, it showed a positive interaction between choampphenicol and an-tipyetic/nagesic drugs.
- Childhood leukemia /
- Iatrogenic /
- Risk factor /
- Case-control study

[1]	Linet MS, Devesa SS. Desoriptive epidemiology of childhood. leukemia. Br J Cancer, 1991, 63: 424.
[2]	Bross IDL. Leukemia from low-level radiation. New Egnl J Med, 1972, 287: 103.
[3]	Shu Xo, Gao YT, Linet MS. Chloramphenicol use and childhood leukemia in Shang hai. Lancet, 1987, 8565: 934.
[4]	Robison LL, Buckley JD, Digle AE, et al. Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. Cancer, 1989, 63: 1904.
[5]	Bruzzi P, Green SB, Byar DP, Estmating the popula-tion attributable risk for multiple risk factors using case-control date. Am J Epidemiol, 1985, 122: 904.
[6]	王天爵.交互作用的估计及其应用( 一、二) .中国卫生统计, 1989, 6(6): 5 6; 1990, 7(l): 62.
[7]	Rothman KJ. Modern epidemiology. Boston, Little, Brown and ComPany, 1986: 311. 327.
[8]	Shu XO, Gao Yt, Brinton LA. A population based case-control study of childhood leukemia in Shang hai. Cancer, 1988, 62: 635.
[9]	God K. Chloramphenicol use and chromosomal mor-phology, J Med, 1979, 10: 159.