The diagnosis value of the determination of serum AIPha-1-antitrypsin of lung and varied digestive cancers
-
摘要: 作者对测定血清α1-抗胰蛋白酶（α1－AT）常用的胰酶活性抑制法和免疫电泳法进行了比较，并用两法同时测定了肺癌及非癌性肺疾病和肝癌、胰腺癌等五种消化系统恶性肿瘤患者血清α－AT含量。结果显示，肺癌及非癌性疾病组血清α－AT水平均显著高于正常对照组（P<0．001），肺癌组明显高于非癌性肺病组（P<0．05）；测定各消化系统肿瘤组血清α1－AT含量均明显比对照组升高（P<0．001）。结果表明恶性肿瘤发生时，α1－AT作为急性相反应物可非特异性上升，高于非癌性疾病，对恶性肿瘤的诊断及鉴别有一定临床价值。两种测定方法相比免疫电泳法为较好的临床血清α1－AT测定法。Abstract: In this experiment we compare two test emthods to determine the serum alpha-1-antitrypsin(α1-AT) level, the enzymatic and immunoelectrophoresis methods. With the both methods we measure the α1-AT concentration in the serum of neo-plastic and non-neoplastic lung diseases and varied digestive cancers including hepat-ic, panereatic, esophageal cancers. The results from both test methods give identi-cal finding, which indicate that the serum α1-AT level of lung cancer is significantly higher than that of normal control(P<0.001) and it is also higher than that of non-neoplastic lung diseases according to only immunologiecal method(P<0.05). The serum α1-AT level of all determined five sorts of digestive cancers are higher than that of normal control nonspecificly(P<0.001). The results show that, as a sort of acut phase reactants, serum α1-AT level may elevate in varied cancers non-specificly, and may be higher than that of non-neoplastic disease so it may have clin-ical meaning for diagnosis or screen of these cancers. Comparing the both test meth-ods of serum α1-AT we think the immunoelectrophoresis method may be better se-lection for clinical usage.
-
Key words:
- α1-antitrypsin /
- digestive cancers /
-
-
[1] 张强华, αl抗异蛋白酶(综述). 国外医学微生物分册, 1992, 14(4): 180. [2] 李定国, 阎兰. α1抗异蛋白酶异质体的检测及其诊断价值. 中华医学检验杂志, 1990, 13(3): 141. [3] Dietz AA, Rubinstein HM, Hodges LH. Measurement of alpha-l-antitrypsin in serum by immunodiffusion and by enzymatic assay. Clin. Chem, 1974, 20: 396. [4] 关赛芳, 徐世康 陈复华. 火箭免疫电泳法检侧人血清α1抗胰蛋白酶. 中华医学检验杂志. 1948, 7(2): 8. [5] Chio LF, Oon CJ. Changes in serum alpha-l-antit-rypsin, alpha-l-acidglyco protein and beta-2-glyeopro-teins with malignant hepatocellular carcinoma. Can-cer, 1979, 43(2): 596. [6] 胡连林, 沈寒放, 刘听. 肺癌患者血清α1抗胰蛋白酶检测临床意义. 第三军医大学学报, 1992, 14(2):188. [7] 宋茂民 ,何三光, 田雨霖, 等. 等电聚焦血清Q:抗胰蛋白酶诊断胰腺癌和肝外胆道癌的研究. 中国医科大学学报, 1994, 23(增刊): 46. [8] Goetz IE ,Weinstein G, Roberts E. Effects of protease inhibnitions of growth of hamster tumour cells in cul-ture. Cancer Res, 1972, 32: 2469. [9] Arora PK, Miller HC, Aronson LD. αl-antitrypson is an effector of immunological Stasis. Nature, 1978, 274: 589. [10] Sekine C, Aoyagi Y, Suzuki Y. The reactivity of al-pha-l-antitrypsin with lens culinaris agglutinin and its usefulness of the liver. Br. J. Cancer, 1987, 56: 371
计量
- 文章访问数: 1031
- HTML全文浏览量: 25
- PDF下载量: 421
下载:
