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善得定诱导卡铂腹腔淋巴化疗的实验研究

汪邵平, 王强, 王元和, 李全业

汪邵平, 王强, 王元和, 李全业. 善得定诱导卡铂腹腔淋巴化疗的实验研究[J]. 肿瘤防治研究, 1998, 25(5): 370-372.
引用本文: 汪邵平, 王强, 王元和, 李全业. 善得定诱导卡铂腹腔淋巴化疗的实验研究[J]. 肿瘤防治研究, 1998, 25(5): 370-372.
Wang shaopin, . Sandostatin modulation of lymphatic drug exposure following intraperitoneal administration of carboplatin[J]. Cancer Research on Prevention and Treatment, 1998, 25(5): 370-372.
Citation: Wang shaopin, . Sandostatin modulation of lymphatic drug exposure following intraperitoneal administration of carboplatin[J]. Cancer Research on Prevention and Treatment, 1998, 25(5): 370-372.

善得定诱导卡铂腹腔淋巴化疗的实验研究

详细信息
  • 中图分类号: R730.5

Sandostatin modulation of lymphatic drug exposure following intraperitoneal administration of carboplatin

  • 摘要: 为探讨善得定对腹腔化疗中淋巴药物浓度的影响,对16只兔腹腔注入卡铂50mg十生理盐水100ml,实验组加用善得定,分取门静脉血、外周血、淋巴液,应用原子吸收光谱法测定样本铂浓度.结果显示:实验组淋巴铂浓度达峰后可维持较高水平,其药-时曲线下面积(AUC)显著增加.外周血铂浓度却下降明显.提示:在卡铂腹腔化疗中应用善得定能提高化疗药物在淋巴中的作用效能,达到诱导腹腔淋巴化疗的目的.同时又可进-步减轻化疗药物的全身毒副反应.

     

    Abstract: To examine the effect of sandostatin to lymph drug concntration following intraperitoneal(IP)chemotherapy,50mg carboplat was injected into Rabbits IP along with 20ug/h sandostatin as a continous Ⅳ infusion in one group and no sandostatin in the control group.The platinum in lym-ph,jugular vein and protal vein over the ensuring 8 hous were measured by the flameless atomic abshaption spectoscopy.The result show:for the experimental whinals,the Platinum in lymph remain a higher level even after reaching the peak concenhation,result in the increasing of AUC(0- 8)(P<0.01).In contrast,it kept on decreasing in jugular vein(P<0.01).This Permitted an indirect estimate of the effect of sand-ostatin on the rate of carboplatin movement from the peritoneal cavity to the local lymph,so become the candidate to induce intra-abdominal lymphatic chemotherapy with more lower system reaction.

     

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出版历程
  • 刊出日期:  1998-10-04

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