Sandostatin modulation of lymphatic drug exposure following intraperitoneal administration of carboplatin
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摘要: 为探讨善得定对腹腔化疗中淋巴药物浓度的影响,对16只兔腹腔注入卡铂50mg十生理盐水100ml,实验组加用善得定,分取门静脉血、外周血、淋巴液,应用原子吸收光谱法测定样本铂浓度.结果显示:实验组淋巴铂浓度达峰后可维持较高水平,其药-时曲线下面积(AUC)显著增加.外周血铂浓度却下降明显.提示:在卡铂腹腔化疗中应用善得定能提高化疗药物在淋巴中的作用效能,达到诱导腹腔淋巴化疗的目的.同时又可进-步减轻化疗药物的全身毒副反应.Abstract: To examine the effect of sandostatin to lymph drug concntration following intraperitoneal(IP)chemotherapy,50mg carboplat was injected into Rabbits IP along with 20ug/h sandostatin as a continous Ⅳ infusion in one group and no sandostatin in the control group.The platinum in lym-ph,jugular vein and protal vein over the ensuring 8 hous were measured by the flameless atomic abshaption spectoscopy.The result show:for the experimental whinals,the Platinum in lymph remain a higher level even after reaching the peak concenhation,result in the increasing of AUC(0- 8)(P<0.01).In contrast,it kept on decreasing in jugular vein(P<0.01).This Permitted an indirect estimate of the effect of sand-ostatin on the rate of carboplatin movement from the peritoneal cavity to the local lymph,so become the candidate to induce intra-abdominal lymphatic chemotherapy with more lower system reaction.
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Key words:
- carboplatin /
- sandostatin /
- intraperitoneal chemotherapy /
- lymphatic chemotherapy
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