The relationship between the PCNA,P53 overexpression and Prognosis of squamous cell carcinoma of larynx
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摘要: 探讨PCNA、P53的过度表达与喉癌预后的关系.方法:应用免疫组化ABC法对56例喉鳞癌和7例喉正常组织检测.结果:56例喉癌中,PCNA、P53阳性率分别为71.4% 和 51.8%.正常组织染色阴性.喉癌的临床分期、有无淋巴结转移和患者术后3年生存率与PCNA、P53 阳性表达率关系密切.结论: PCNA、P53的过度表达与喉癌的不良预后有关.Abstract: In order to approach the significance of PCNA,P53in laryngeal carcinoma,immunohistochemical staining method was used to detect the proteins of PCNA,P53 in 56 cases of squamous cell carcinoma of larynx and 7 cases of normal larynx tissues.The positive incidences of PCNA,P53in laryngeal carcinoma were 71.4% and 51.8%,respectively.No protein was found in normal tissuse.Overexpression of PCNA, P53were positive correlated to clinical stage,lymphatic node metstasis and patient survival rates of this tumor.The overexpression of PCNA,P53 are closely correlated with the poor prognosis of laryngeal carcinoma.
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Key words:
- Proliferating cell nuclear antigen /
- Protein /
- P53 /
- Larynx neoplasms /
- Cancer /
- squamous cell /
- Prognosis
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