PCNA、P<sup>53</sup>的过度表达与喉鳞癌预后的关系

PCNA、P⁵³的过度表达与喉鳞癌预后的关系

摘要: 探讨PCNA、P⁵³的过度表达与喉癌预后的关系.方法:应用免疫组化ABC法对56例喉鳞癌和7例喉正常组织检测.结果:56例喉癌中,PCNA、P⁵³阳性率分别为71.4% 和 51.8%.正常组织染色阴性.喉癌的临床分期、有无淋巴结转移和患者术后3年生存率与PCNA、P⁵³ 阳性表达率关系密切.结论: PCNA、P⁵³的过度表达与喉癌的不良预后有关.

Abstract: In order to approach the significance of PCNA,P⁵³in laryngeal carcinoma,immunohistochemical staining method was used to detect the proteins of PCNA,P⁵³ in 56 cases of squamous cell carcinoma of larynx and 7 cases of normal larynx tissues.The positive incidences of PCNA,P⁵³in laryngeal carcinoma were 71.4% and 51.8%,respectively.No protein was found in normal tissuse.Overexpression of PCNA, P⁵³were positive correlated to clinical stage,lymphatic node metstasis and patient survival rates of this tumor.The overexpression of PCNA,P⁵³ are closely correlated with the poor prognosis of laryngeal carcinoma.