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RB、P53抑癌基因蛋白在甲状腺肿瘤中的表达

蒋昌林, 丁祖玖, 黄裕华, 汪谟庆, 石磊

蒋昌林, 丁祖玖, 黄裕华, 汪谟庆, 石磊. RB、P53抑癌基因蛋白在甲状腺肿瘤中的表达[J]. 肿瘤防治研究, 1998, 25(4): 270-272.
引用本文: 蒋昌林, 丁祖玖, 黄裕华, 汪谟庆, 石磊. RB、P53抑癌基因蛋白在甲状腺肿瘤中的表达[J]. 肿瘤防治研究, 1998, 25(4): 270-272.
Jiang Changlin, . Expression of retinoblastoma and P53 tumour suppressor gene protein in human thyroid tumours[J]. Cancer Research on Prevention and Treatment, 1998, 25(4): 270-272.
Citation: Jiang Changlin, . Expression of retinoblastoma and P53 tumour suppressor gene protein in human thyroid tumours[J]. Cancer Research on Prevention and Treatment, 1998, 25(4): 270-272.

RB、P53抑癌基因蛋白在甲状腺肿瘤中的表达

Expression of retinoblastoma and P53 tumour suppressor gene protein in human thyroid tumours

  • 摘要: ABC免疫组化法检测77例甲状腺肿瘤和非瘤病变中RB与P53抑癌基因蛋白的表达。所有标本中都有RB蛋白表达,表明RB基因失活在甲状腺肿瘤中不起重要作用。甲状腺非瘤病变与腺瘤中P53全部阴性,甲状腺乳头状癌、滤泡状癌中P53阳性率低(8.3%与15.8%),阳性细胞数也少(<10%),P53主要在甲状腺未分化癌中高表达(66.7%)且与乳头状癌,滤泡状癌有显著性差异,提示P53蛋白异常在甲状腺癌由高分化向未分化发展过程中起关键性作用。

     

    Abstract: We have examined retinoblastoma (RB) and P53protein by immunohistochemistry inseventy-seven formalin fixed, paraffin wax embedded thyroid lessions.Thyroid lessionsstudied included 10 non-neoplastic thyroid tissues, 14 thyroid adenomas, 24 papillarycarcinomas, 19 follicular carcinomas, 9 undifferentiated carcinomas and 1 medullary car-cinoma.The RB protein is not loss in any cases, indicating that inactivatlon of the RBgene is unlikely to play a important role in the pathogenesis of thyroid tumours.Six of 9(66.7%) undifferentiated carcinonlas, 3 of 19(15.8%) follicular carcinomas, 2 of 24 (8.3%) papillary carcinomas show P53protein nuclear staining.In all of P53positive cases, 4of 6 undifferentiated carclnomas showed more positive cells than 5 well-differentiatedcarcinomas in which less than 10 percent of cells had increased P53protein levels.Our results suggest that P53protein abnormalities play a crucial role in the progression of well-differentiated to undifferentiated thyroid carcinomas.

     

  • [1] Ito T, Seyama T, Mizuno T, et al. Genetic alterations i.n thyriod tumor progression: association with P53gene mutations. Jpn J Cancer Res,1993, 84:526
    [2] Fagin JA, Matsuo K, Karmakar A. et al. High prevalence of the P53gene in poorly differentiated human thyriod carcinomas. J Clin Invest, 1993, 91:179
    [3] Xu HJ,Hu SX, Benedict WF. Lack of nuclear RB protein staining in Gu/middle Gt cells:correlation to changes in total RB protein lever. Oncogene,1991,6:1139
    [4] Zou MU, Shi YF, Farid NR. Retinoblastoma gene defects are central to thyriod carcinogenesis. Endocrine Society Meeting 1993. Abstract 162. Endocrinol J, 1993:91
    [5] Holm R and Nesland JM. Retinoblastoma and P53tumour suppressor gene protein expression in carcinomas of the thyriod gland. J Pathol,1994,172:267
    [6] Xu HJ,Hu SX,Cagle PT,et al.Absence of retinoblastoma protein in primary non-small-cell lung carcinomas.Cancer Res,1991,51:2735
    [7] Wright PA,Lemoine NR,Goretzki PE,et al.Mutation of the P53gene in a differentiated human thyriod carcinoma cell line,but not in primary thyriod tumiyrs.Oncogee.1991,6:1693
    [8] Zou MU,Shi YF, Farid NR. P53mutations in all stages of thyriod carcinomas. J Clin Endocrinol Metab, 1993, 77, 70549 Sakamoto A,Kasai N, Sugano H. Poorly differentiated carcinoma of the thyriod. A clinicopathologic entity for a high-risk group of papillary and follicular carcinomas.Cancer, 1983, 52:1849
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  • 刊出日期:  1998-08-04

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