Abstract: To evaluate the response to chemotherapy and relationship on expressionfo P-GP, GST-π, P⁵³, P¹⁸⁵in ovarian carcinomas.methods: lmmunohistochemical technique ABC was used to detect P-GP,GST-π,P⁵³, P¹⁸⁵content in 49 cases of ovarian carcinomas.results: 1.The response rates to chemotherapy of patients with positive stainingof P-GP, GST-π, P⁵³, P¹⁸⁵ were 14% 、27.3%、 41.7%、 24.3% respectively: but thoserates of patients with negative staining were 53.6% (P<0.005)、 56.3% (P<0.005)、48.2% (P<0.05)、 75.0% (P<0.005) respectively.2.There was a close correlation between expression of P-GP and P¹⁸⁵ (P<0.05).conclusions: Expression of P GP,GST-π,P⁵³and P¹⁸⁵ affect the recent results of chemotherapy obviously in ovarian carcinomas.There was a researched value in depth on relationship between expression of P-GP and P¹⁸⁵.