高级搜索

胰腺癌P16蛋白的表达及其临床意义

李玉军, 张炳远, 姜天福, 纪祥瑞

李玉军, 张炳远, 姜天福, 纪祥瑞. 胰腺癌P16蛋白的表达及其临床意义[J]. 肿瘤防治研究, 1998, 25(4): 252-253.
引用本文: 李玉军, 张炳远, 姜天福, 纪祥瑞. 胰腺癌P16蛋白的表达及其临床意义[J]. 肿瘤防治研究, 1998, 25(4): 252-253.
Li Yujun, . Expression and significance of P16 protein in human pancreative carcinoma[J]. Cancer Research on Prevention and Treatment, 1998, 25(4): 252-253.
Citation: Li Yujun, . Expression and significance of P16 protein in human pancreative carcinoma[J]. Cancer Research on Prevention and Treatment, 1998, 25(4): 252-253.

胰腺癌P16蛋白的表达及其临床意义

Expression and significance of P16 protein in human pancreative carcinoma

  • 摘要: 应用免疫组织化学LSAB法检测P16蛋白在胰腺癌中的表达。结果显示,47例胰腺癌P16蛋白表达阳性率为55.3%(26/47);其阳性率与患者性别、年龄、肿瘤大小,病理学类型及组织学分级无关;而与胰腺癌临床分期和患者1年生存率明显相关(P<0.05)。表明P16基因缺失或突变在胰腺癌发生发展的后期发挥重要作用;P16蛋白低表达者预后差。因此P16蛋白可作为胰腺癌的分子生物学标志。

     

    Abstract: The expression of P16 protein in 47 pancreative carcinoma was studied immunohistochemically, 26 cases showed positive staining of P16 protein (55.3%).These immunoreativities were most common in the cytopalsm of tumor cells.There was nosignificant relationship between the expression of P16 protein and tumor sizehistopathologic classification histologic grading or patient's sex and age.However, inverse relationships were observed between P16 protein expression and clinical stage(TNM) (P2 = 5.43, PO.05).Espression of p16protein was Positively associated withpost-operative survival (l year) and the relationship was significant (p= 0.043, P0.05).These results suggset that p16gene play an important role n antimetastasis ofpancreative carcinoma, and mayserve as a indictor to predict the prognosis of patients.

     

  • [1] Kamb A,Gruis NA, Weaver-Feldhaus J, et al. A cell cycle regulator potentially involved in genesis of manr tumor types. Science, 1994, 264:436
    [2] Marx J. How ells cycle toward cancer. Science, 1994,263:319
    [3] Okamoto A, Demetrick DJ,Spillare EA, et al. Mutations and altered expression of Ple(ink4) in human cancer. Proc Natl Acad Sci USA,1994, 91:11045
    [4] 傅松滨.多肿瘤抑制基因MTS1/P16CDK4与性别周期调节.国外医学遗传学分册,1996,19:6
    [5] Reed JA, Loganzo F,Joan JR, et al. Loss of expression of the Ple/cyclin-dependent kinase inhibitor 2 tumor suppressor genee of in melanocytic lesions correlates with invasive tumor progression. Cancer Res, 1995,55:2713
计量
  • 文章访问数:  1043
  • HTML全文浏览量:  18
  • PDF下载量:  302
  • 被引次数: 0
出版历程
  • 刊出日期:  1998-08-04

目录

    /

    返回文章
    返回
    x 关闭 永久关闭