放化疗综合治疗非霍奇金淋巴瘤远期疗效
Treatment of Non - Hodgkin's Lymphomas with Combined Radio-Chemotherapy
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摘要: 作者对72例NHL的治疗方法与预后的关系进行临床探讨。本组结外NHL居多占70.8％，Ⅲ、Ⅳ期病人占45.8％。所有病例均经病理证实。其中22例接受扩大野放射治疗（R组）；50例接受放化疗综合治疗（RC）组。全组3、5、10、15和＞18年生存率分别为61.1％、54.0％、43.8％、35.0％和31.3％。其中R组3、5、10、15和18年以上生存率分别为59.1％、53.2％、23.3％、11.1％和（0/5）；RC组分别为61.4％、57.7％、53.2％、41.1％和38.3％。尽管RC组病情较R组严重，但其各年生存率均高于R组，尤以10年以上生存差别显著。初步结果显示放化疗综合治疗NHL是提高远期生存率的有效方法之一。Abstract: Theraputic result of 72 patients with non Hodgkin's lymphomas (NHL) are evaluated. 70.8% of the cases were out of the lymph nodes, 45.8% at Ⅲ、Ⅳstage. Allpathologically comfirmed. 22 patients received extansion field radiotherapy (R); 50 pa-tients received radiotherapy combined with chemotherapy (RC). The overall survivalrates of 3、5、10、15 and18yean were 61.1 %、54.0%、43.8%、35.0% 、and 31.3%， respectively. the 3、5 、10、15 and 18 year survival rates were 59.1%、53.2%、23.3%、11.l% and (0/5)in R group; 61.4% 、57.7% 、53.2% 、41.1% and 38.3% in RC group，re-spectively. Although the condition of the patients in RC group was more severe than Rgroup, The long term survival rates in RC group were higher than those in R group.The preliminary results shown that radiotherapy combined with chemotherapy is moreeffective in improving long term survival rates for NHL than radiotherapy alone.
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Key words:
- lymphoma /
- non-Hodgkin's /
- Radio-Chemotherapy /
- Long-term survival
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1. 勇威本, 张运涛, 卫燕, 等. 200例非霍奇金淋巴瘤预后分析. 中华肿瘤杂志, 1997, 19(3):212 2. The International Non-Hodgkin’s Lymphoma Prognostic Factor Project. A predictive model for aggressive non-Hodgkin’s Lymphoma. N Engl J Med, 1993, 329:987 3. A. Daban, T. Fouillard. Ⅰ、Ⅱ期高度恶性非何杰金氏淋巴瘤的综合治疗. 中国放射肿瘤学, 1991, 5(4):235 4. 黄一容, 顾大中, 王奇璐, 等. 恶性淋巴瘤的综合治疗. 中华放射肿瘤学杂志, 1997, 6(2):77 5. 胡久望. 非何杰金淋巴瘤的综合治疗. 中国放射肿瘤学, 1990, 4(2):127 6. 王奇璐, 宋少章, 徐宾河, 等. 非何杰金氏淋巴瘤276例化疗有/无放疗临床研究. 肿瘤防治研究, 1991, 19:163 7. 周立强, 王奇璐, 冯奉仪, 等. 98例晚期NHL疗效和毒性观察. 中华放射肿瘤学杂志, 1994, 3(3):176
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