微量元素与消化道癌Logistic回归分析及临床意义
Logistic Regression Analysis on Trace Elements and Digestive Tract cancer and Clinical significance
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摘要: 本文测定了130例食管癌，100例胃癌，60例结直肠癌，22例肝癌，56例消化道良性疾患。结果表明：消化道癌患者血清中铜，铁含量，铜/锌比显著高于健康人（P＜0.05～P<0.001），锌，钙含量明显低于健康人（P<0.05～P
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关键词:
- 消化道癌 /
- 血清 /
- 微量元素 /
- Logistic回归分析
Abstract: The paper determined serum copper,zine,iron,manganese,calcium levels in esophagus cancer(130 cases). stomatch cancer(100cases). rectal cancer(6Ocases)and liver cancer(22 cases)and various digestive tract benign discases(56 cases). The results showed that serum copper,iron levels,Cu/Zn ratio were significantly higher and zine,calcium levels were significantly lower in digestive tract cancer than in healthy subject and in other digestive tract benign discases(P<0. 05～P<0. 001),stage Ⅲ～Ⅳ and metastatic carcinoma patients copper level,Cu/Zn ratio were significantly higher and zinc level was significantly lower than that in stage Ⅰ～Ⅱ(P<0. 05～P<0. 001),Cu/Zn ratio have a sensitivity 72% on esophagus cancer,68% on stomach cancer,59% on rectal cancer,80% on liver cancer,Cu/Zn ratio can be used as a diagnosis in patients with digestive tract cancer. And it has a certain role in recognizing digestive tract cancer from high risk group. Multi-variable logistic regression analysis showed serum Cu,Cu/Zn ratio elevation maybe the dangerous factors of digestive tract cancer and serum zinc,calcium may have inhibition action to digestive tract cancer.-
Key words:
- Digestive tract cancer /
- Serum /
- Trace elements /
- Logistic regression
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1. Inutsuka S, Araki S. Plasma copper and zinc levels in patients with maliganant tumor of digestive organs:Clinical evaluation of the Cu/Zn ratio. Cancer, 1978, 42:626 2. Gorodetsky R, Fuks Zv. Sulkes A, et al. Correlation of erythrocyte and plasma levels of zinc and iron with evdence of metastatic spread in cancer patients. cancer, 1985, 55:779 3. Diez M, Cerdan FJ, Arroyo M, et al. Use of the Copper/zinc ratio in the diagnosis of lung of cancer. Cancer, 1989, 63:726 4. 金丕焕主编. 医用统计方法. 上海医科大学出版社, 1993 5. NAPS. 微量元素与食管癌发生的关系. 国外医学卫生学分册, 1994, 11(3), 109 6. Lipkin M. Effect of added dietary calcium at high risk for familial colonic cancer. N Engl J Med, 1985, 313:1381 7. 杨工, 高玉堂, 季步天, 等. 不同来源膳食纤维, 钙与结直肠癌关系的研究. 中华预防医学杂志, 1994, 28, 195 8. 王立东, 裘宋良, 杨观瑞, 等. 饮食补钙对人食管上皮癌前病变的影响. 中华肿瘤杂志, 1990, 12:332 9. Joseph V, Selby Gary D. Epidemiologic evidence of an association between body iron storesand risk of cancer. Cancer, 1988, 41:677
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