Abstract: To evaluate the relationships and their significance between endocrine differentiation and P⁵³Protein or epidermal growth factor receptor(EGFR)expression in colorectalcarcinoma. Methods: Expression of chromogranin A (CGA), P⁵³and EGFR weredetectedin 79surgical specimen using immunohistochemistry ABC technique Results: The incidences ofCGA, P⁵³and EGFR expression in the cancerous tissues were 35.4 % (28/79), 60.8 % (48/79 )and 30.4 % (24/79), respectively, The expressive rate and the number of P⁵³ immunostainingtumor cells in the tumor lesions with endocrine differentiation were 78.6 % (22/28) and 984.3±702/mm² and in the samples without endocrine differentiation 51.0% and 589.5±489.5/mm². The differences of P⁵³expression between the two groups were significant (P0.025;PO.05). The rate of EGFR expression in the tumor with and without endocrine differentiation were 46.4% (13/28) and 21.6 % (11/51 ),respectively. Their difference was also statistically significant (P0.025 ). Conclusion: The expression of P⁵³ and EGFR are statisticallyhigher in the colorectal cancer with endocrine differentiation than that in the cases withoutendocrine differentiation. It indicates that the explession of P⁵³ and EGFR may be correlatedwith the endocrine differentiation of colorectal carcinoma.