有和无内分泌分化大肠癌P53和表皮生长因子受体表达的比较研究
A control study on the expression of P53 and EGFR in colorectal carcinoma with and without endocrine differentiation
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摘要: 目的：研究大肠癌内分泌分化与P53表皮生长因子受体（EGFR）表达的关系及意义。方法：采用免疫组织化学ABC法，检测79例大肠癌手术切除组织中嗜铬蛋白A（CGA），P53及EGFR的表达变化。结果：大肠癌组织中CGA，P53及EGFR的表达率分别为：35.4％（28/79〕，60.8％(48/79）和30.4％（24/79），有内分泌分化的大肠癌P53表达率及其免疫阳性细胞数分别为78.6％（22/28）和984.3士702.0/mm2，无内分泌分化者分别为51.0％和589.5士489.5/mm2，前者明显高于后者（PAbstract: To evaluate the relationships and their significance between endocrine differentiation and P53Protein or epidermal growth factor receptor(EGFR)expression in colorectalcarcinoma. Methods: Expression of chromogranin A (CGA), P53and EGFR weredetectedin 79surgical specimen using immunohistochemistry ABC technique Results: The incidences ofCGA, P53and EGFR expression in the cancerous tissues were 35.4 % (28/79), 60.8 % (48/79 )and 30.4 % (24/79), respectively, The expressive rate and the number of P53 immunostainingtumor cells in the tumor lesions with endocrine differentiation were 78.6 % (22/28) and 984.3±702/mm2 and in the samples without endocrine differentiation 51.0% and 589.5±489.5/mm2. The differences of P53expression between the two groups were significant (P0.025;PO.05). The rate of EGFR expression in the tumor with and without endocrine differentiation were 46.4% (13/28) and 21.6 % (11/51 ),respectively. Their difference was also statistically significant (P0.025 ). Conclusion: The expression of P53 and EGFR are statisticallyhigher in the colorectal cancer with endocrine differentiation than that in the cases withoutendocrine differentiation. It indicates that the explession of P53 and EGFR may be correlatedwith the endocrine differentiation of colorectal carcinoma.
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