Abstract: We identified that 10ug/ml Doxorubicin can induce the MEC—1 cell apoptosis. And then we studied the changes of cell cycle during the MEC—1 cells apoptosis.These would benefit to the clinic chemotherapy for the mucoepidermoid carcinoma. Methods:we observed the morphological changes of the MEC—1 cell by microscopy after the cells exposing to 10ug/ml Doxorubicin and apoptosis was detected by the DNA gel electrophoresis. We used FCM to study the changes of cell cycle in the MEC—1cell line. Results:The morphological changes of cell apoptosis observed and the DNA gel electrophoresis show the typical apoptotic ladder.The MEC—1 cells arrested in G₂ phase at 5h after administration of 10ug/ml Doxorubicin and were blocked in G₁ Phase at 24h. Conclusions:In the first time of the MEC—lcells exposing th 10ug/ml YDoxorubicin,the cells arrested in G₂ Yphase. Later,the cells were blocked in G₁ Phase and induced apoptosis.