EB病毒ZEBRA lgG抗体变化规律和鼻咽癌发病的关系
The Relationship between EB Virus ZEBRA/igG Change Regulation and Nasopharyngeal Carcinoma
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摘要: 目的 研究ZEBRAIgG 在鼻咽癌癌变不同阶段的动态变化规律。方法 对四会地区鼻咽癌筛查人群的血清库不同时期的标本用ELISA 法检测ZEBRAIgG,包括：鼻咽癌27 例，高危人群50 例，单阳人群50 例，全阴人群30 例。结果 鼻咽癌组ZEBRAlgG的阳性率为90-9%, 高于各对照组，差异均有显着性（P<0-01）.从ZEBRAIgG出现阳性至病理确诊时的时间平均为3-5（2-62～4-38） 年，且至病理确认时抗体水平逐渐升至最高。结论 ZEBRAIgG可作为一个诊断鼻咽癌的指标，抗体持续高水平或抗体水平持续升高者应高度怀疑鼻咽癌。Abstract: Objective to explain the change regulation of ZEBRA/IgG in the different state of nasopharyngeal canceration. Methods ZEBRA/IgG were detected in ELISA method to the different state screening samples in suihui area.including:nasopharyngeal carcinoma 27,high risk people 50,VCA/IgA positive person 50,all negative person 30. Results The positive rate of ZEBRA/IgG in the group of NPCwre 90 9%,which is higher than the contrast groups.There is significance between them(P0 01).The average time from ZEBRA/IgG first positive to be pathonalagly diagnosised is 3 5(2 62 4 38)years and the titer of the antibody gradually rise to the highest level. Conclusion The study suggested that ZEBRA/IgG might be as a diagnosis marker to NPC.The patients whose ZEBRA/IgG consistly keep high or rise should be highly suspected of NPC.
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