Abstract: Objective to compare the effect of chemo raditherapy and single radiotherpy to esophageal cancer. Methods 248 patients with esophageal cancer were randomly divided into the combination treatment group of 125 cases and single radiotherpy group of 123 cases.In combined group,DDP(50mg/m 2,day1,8)and 5 Fu(750mg/m 2,day 2～6)were administered by IV per three weeks,persantin 50mg po three times a bay,radiotherpy(DT60～70GY/6 5～7 5 weeks)followed 2～3 cycle chemotherapy later.Single radiotherpy group were treated by radiation(DT60～70GY/6 5～7 5 weeks)only. Results The comparative observation of the two groups showed that:the short term effects were similar, in the combined therapy group,the patients of complete remission and 1 year,3 year,5 year survival rates was higher than single radiotherapy group (p0 05). Conclusion Chemotherapy radiotherayp sequential therapy is effective and safety method for the patients of esophageal carcinoma.