肺癌患者血浆VIP、SP等神经多肽的变化

Plasma Neuropeptide Contents in Patients with Lung Cancer

摘要: 目的测定肺癌患者血浆三种神经多肽的变化。方法 103 例未经治疗的肺癌患者空腹采血，血浆P物质（SP）、生长抑素（SS）、血管活性肠肽（VIP）及癌胚抗原（CEA）均采用放免法。结果肺癌患者SP、SS均明显高于正常对照组，而VIP明显降低。三型肺癌间SP、VIP及SS无明显差别。VIP与SP、SS均呈明显负相关，SP与SS呈明显正相关。三种神经多肽与CEA 无明显相关性。结论三种神经多肽的测定有助于肺癌的诊断及免疫功能的研究，但对肺癌分型无明显价值。

Abstract: Objective To measure the contents of 3 neuropeptides in patients with lung carcinoma. Methods Plasma concentrations of three polypeptides,substance P(SP),somatostatin(SS),vasoactive intestinal polypeptide(VIP) were determined by radioimmunologic method in patients with lung cancer and 63 controls.Reaults SP,SS were significantly elevated while VIP obviously lowered in patients with lung cancer than those in normal controls.There were no statistical difference among SP,SS and VIP in patients,respectively.SP was positive to SP,VIP was negative to SP and SS.There were no correlation between 3 neuropeptides and CEA. Conclusion Detected plasma concentrations of 3 neuropeptides were helpful to diagnose and study immunological function in lung cancer.