食管小细胞癌临床病理及免疫组织化学研究

The Clinicopathology and Immunohistochemical Study of Esophagus Small Cell Carcinoma

摘要: 目的研究食管原发小细胞癌的临床病理特征及其组织发生。方法采用免疫组织化学方法。结果单纯小细胞癌7 例，中间细胞型4 例，混合型3 例。免疫组织化学上，细胞角蛋白阳性10 例，上皮膜抗原阳性12 例，NSE阳性13 例，嗜铬粘蛋白A阳性6 例，突触素阳性4 例。随访病例中6 例在半年内死亡。结论本研究证明食管小细胞癌是一种高度恶性的肿瘤，组织发生上支持来自全能干细胞。

Abstract: Objective study the clinic pathological character and histogenesis of primary esophagus small cell cancer. Methods use the immunohistochemistry. Results 7 cases were pure small cell types,4 intermediate types,3 combined types.Immunohistochemically,ten cases showed positive immunoreaction to cytokeratin.EMA.NSE.Chromogranin A Synaptophysin 12.13.6.4 cases,respectively.Among the patients which obtained follow have 6 case died within half year. Conclusion this study indicate that small cell carcinoma of esophagus is highly malignancy,support its histogenesis may origin from the multipotent stem cells.