Abstract: objective:Purpose 31cases of advanced malignant tumor treated by Paclitaxel are reported. Methods :The patients received Taxol containing combination chemotherapy,And standardised anti allergic durgs are used to patient. Results :Good effects of paclitaxel treatment showed 70 96%,Myelosuppresion is the principal toxicity,None case was died of durg allergy.conclusion:Taxol is a drug of choice in the treatment of advanced malignant tumors who are resistant to conventional chemotherapy.