血清总唾液酸在食管癌早诊中的研究
Study of Serum Total Sialie Acid in Early Iagnosis for Esophageal Cancer
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摘要: 目的：探讨血清总唾液酸对食管癌早诊的作用。方法：采用化学比色法对我国食管癌高发区之一—磁县1510例普查人群的血清总唾液酸(TSA)分析研究。结果：高发人群血清TSA含量随食管上皮细胞增生加重逐渐增加。方差分析显示食管癌、近癌、重增Ⅱ与重增Ⅰ、轻增、正常人群血清TSA含量具有显著性差异(P<0.01)，食管各级病变血清TSA含量两两比较的q检验结果表明：在食管上皮细胞重增Ⅱ时TSA含量与正常人群就有显著性差异(P<0.01)，而重增Ⅰ、轻增和正常人群TSA无显著性差异(P>0.05)。结论：提示血清TSA含量可作为一种食管癌早诊指标用于人群筛查工作。Abstract: Levels of serum total sialic acid (TAS) among 1510 subjects from cixian,one of the place highest incidence of esophageal cancer were detected by technique of chemical colorimetric method.The results show that TSA levels increase with extent of hyperplasia in esophageal epithelial cell.Analysis of variance show the difference of serum TSA levels were significant among esophageal cancer,near cancer,dysplasia Ⅱ and dysplasia I,hyperplasia,normal ( P 0 01).q test between all grading lesion show TSA levels were significant in dysplasia Ⅱ with normal ( P 0 01).While TSA levels were not in dysplasia Ⅰ with normal ( P 0 05).The assay indicate that levels of serum TSA may be helpful as a norm of early diagnosis of esophageal cancer among subjects.
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Key words:
- esophageal cancer /
- chemical colorimetic method /
- Serum total sialic acid
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1 Katopodis N,et al. Lipid-associated sialic acid test for the detecti on of human cancer.Cancer Res,1982,42:5270 2 Dnistrian AM,Schuartz NK.Lipid-bound sialic acid as a tumor marker.Ann Clin Lab Sci,1983,13:137 3 陈煜清，等.癌患者血清唾液酸含量动态变化与癌的消减、复发、转移的关系.中华肿瘤 杂志.1979，1(1)：29 4 王显臣，等.癌患者血清唾液酸测定及紫色反应的临床意义.实用肿瘤杂志，1992，6(3) ：46 5 李琰，等.血清总唾液酸水平检测在肺癌临床诊断中的意义.河北医药，1997，19(3)：16 8
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