Abstract: Objective:To study the value of serum β Glucuronidase(β G) detection in the hepatic carcinoma diagnosis. Methods :We establish the ELISA method to detect the serum activity of β G in patients of liver cancer and patients suffered from various kinds of tumour diseases,and clear the change of serum β G in patients of hepatic carcinoma before and after treatment. Results :The serum β G activity of hepatocellular carcinoma patients was significantly higher than that in lung cancer and stomach cancer and thyroid carcinoma.And it was significantly higher than that in liver cirrhosis and hepatoangioma ( P 0 01).The serum β G level decreased markedly ( P 0 01) after operation or interrenien therapy.The activity of β G was significantly higher after relapse. Conclusion :As a marker of enzyme,β G appears to be helpful in diagnosis,treatment and prognosis of hepatocellular carcinoma.