Abstract: 23 Cases with cancer of head of pancreas were treated in our hospital from 1980～1992.All cases were explored by laporotomy and the diagnosis of all cases were comfirmed by histopathology.Of 23 cases,pancreatoduodenectomy was performed in six cases,local resection in one case,the resectable rate was 30.4%,the lower resectable rate was due to advanced stage in the most of patients.In the non-resection group,the average survival time was 5.2 months,the one year survival rate was 18.8%.The clinical characteristics, the value of diagnosis of ultrosonic wave and CT,how to raise the positive rate of pathology and the resection rate were discussed in this article.