Abstract: Objective To evaluate the diagnostic value of CT in the neoplasm of maxillary sinus. Methods The CT images of 38 cases with maxillary sinus neoplasm confirmed by surgery and pathology were retrospectively analyzed. Results 23 cases of maxillary sinus neoplasm were malignant,15 cases were benign The key points to diagnose and differentiate were that whether the shape of the mass was regular,the density of the mass was uniform and the change of maxillary bone was hypertrophy,expansive,remodeling or destructive.The fat around the maxillary sinus was infiltrated or not. Conclusion CT scanning is helpful to diagnose and differentiate the nature of maxillary sinus neoplasm,and provides important information for the clinicians to plan proper surgical treatment.