15例恶性胸腺瘤化疗临床总结

A Study of Chemotherapy for Malignant Thymoma on 15 Patients

摘要: 目的评价恶性胸腺瘤不同化疗方案的选择与疗效间的关系。方法本文回顾性总结T1978－1997年12月间15例晚期恶性胸腺瘤患者接受化疗的资料,其中接受含DDP方案7例,不含DDP方案8例。结果总有效率（RR）20％（3／15）,中位生存期14个月：其中接受含DDP方案者RR0,中位生存期9．5个月；接受不含DDP方案者RR37．5％中位生存期14个月,P＜0．05。结论含顺铂方案治疗恶性胸腺瘤在疗效上及患者生存时间上并不优于不含顺铂方案。

Abstract: Objective To evaluate the effects of different chemotherapeutic projects on malignant thymoma. Methods The retrospective study summarized the data of 15 cases of phase Ⅲ.Ⅳ malignant thymoma from 1978 to Dec.1997. Results There was 0/7 RR in the group with cisplatin, the MTS were 9.5 months,while 3/8 RR in the other group without cisplatin,the MTS was 14 months;and the overall response rate was 20%,while the MTS was 14 months.There is statistical difference in rsponse between the two groups (P<0.05). Conclusion The chemotherapy with cisplatin did not get better of the chemotherapy without cisplatin in comparison of effect and survival time.