Abstract: Objective To investigate expression of P⁵³.Bcl-2.P¹⁶ and c-myc genes in ovarian epithelial tumors and relationship between expression and genesis and prognosis and its role. Methods Application Immunohistochemistic Methods ,studied expression of P⁵³.Bcl-2.P¹⁶ and c-myc genes in ovarian epithelial tumors included 80 cases benign.26 borderline and 116 malignant tumors. Results expression on rates of P⁵³.Bcl-2.P¹⁶ and c-myc were36.48%,27.4%,83.33% and 52.25% respectively.The expression of c-myc was increased with malignancy high,It has significant different between benign and malignant(P＜0.01).The expression rate of P¹⁶ was decreased with malignancy high and it has significance concern with tumor behavior(P＜0.01).The expression of P⁵³.Bcl-2 and c-myc in ovarian malignant tumor were related to the stage.