Abstract: Objective Analysis the clinic characteristic.pathologic diagnosis and differential diagnosis of angiosarcoma of breast. Methods Analysis the clinic characteristic and detect the expression of F8-related antigen.Vimentin and CK of the 4 cases angiosarcoma of breast. Results Among the 4 cases,there are 2 cases have local recurrent after simple mass resection,and there are 3 cases died in 7.11.24 months after treatment respectiveely,and 1 case survived for 16 years,Conclusiton The angiosarcoma of breast is a highly malignant tumor,its prognosis related with neoplastic differential degree.