小儿非何杰金淋巴瘤P<sup>53</sup>基因突变与预后的研究

小儿非何杰金淋巴瘤P⁵³基因突变与预后的研究

摘要: 目的: 探讨小儿非何杰金淋巴瘤(NHL)P⁵³基因突变与预后的关系。方法: 31例颈部与腹部Ⅱ、Ⅲ期NHL 患儿, 应用PCR-SSCP技术检测石腊标本中P⁵³基因第5-6外显因子, 并对31例患者进行了近8年的随访。结果: 31例中11例存在着P⁵³基因突变, 此11例中有7例复发。而无P⁵³基因突变20例中仅1例复发。结论: 说明小儿NHL中P⁵³基因突变是不良预后的指标, 与早期复发有关。

Abstract: Objective: To explore the relation between the Gene Mutation of P⁵³ and Prognosis in pediatric Non-Hodgkin Lymphoma. Methods: To detect the 5 -6 exon of P⁵³ gene in 31 Ⅱ-Ⅲ phases pediatric Non-Hodgkin Lymphoma patients by PCR-SSCP technique and follow-up study them for 8 years. Results: The gene mutation of P53were found in 11 children (11/31)and the recurrecewere observed in 7 of them. The recurrece was only observed in 1 patient of 20 children without gene mutation of P⁵³. Conclusion: The gene mutation of P⁵³ is one of the indicators of prognosis in pediatric Non-Hodgkin Lymphoma and is related with recurrence in early stage.