宫颈鳞癌组织HPV16/18 感染与多个癌基因产物表达的研究

Study of HPV16/18 Infection and Expression of Multiple Oncogene Product in Cervical Squamous Carcinoma

摘要: 目的　探讨 HPV1 6、1 8的感染及多个癌基因的激活在宫颈鳞癌发生发展中的作用。方法　采用免疫组化方法对 1 9例慢性宫颈炎、40例宫颈上皮内瘤变 ( CIN)及 70例浸润性宫颈鳞癌进行 E6、PCNA、p5 3、p2 1 ras和 c- myc蛋白检测。结果　CIN 和浸润性宫颈鳞癌组 E6、PCNA、p5 3、p2 1 ras阳性率明显高于慢性宫颈炎、CIN 和 CIN, 而其 c- myc阳性率则明显低于其它几组。结论　 HPV1 6、1 8的感染及 PCNA、p5 3、p2 1 ras、c- myc的异常表达与宫颈鳞癌的发生发展密切相关。

Abstract: Objective To study the infection of HPV16/18 and the presence of multiple oncogene on the carcinogenesis of cervical squamous carcinoma. Methods Immunohistochemical method was used to detect E6?PCNA?p53?p 21ras and c myc protein expression in 19 cases of chronic cervicitis?40 cases of cervical intraepithelial neoplasm (CIN) and 70 cases of invasive cervical carcinoma. Results A high positive expression rate of E6?PCNA?p53?p 21ras was found in CINⅢ and invasive cervical carcinoma which c myc positi...