唾液酸在宫颈癌组织中的表达及意义

Expression of sialic acid in carcinoma of uterine cervix

摘要: 目的　探讨唾液酸在宫颈癌组织的表达及意义。方法　采用凝集素组织化学染色技术检测了70例宫颈癌组织、3 0例不典型增生组织和 1 0例正常宫颈组织唾液酸的表达, 应用图像分析系统定量分析其表达水平。结果　唾液酸在非癌细胞中无表达, 在宫颈癌组织中的表达与病理类型无关 (P >0 .0 5 ), 在细胞分化程度低、临床分期晚、发生转移、复发及预后差的患者中高表达 (P <0 .0 1或P <0 .0 5 )。结论　唾液酸可作为反映宫颈癌的恶性潜能和预后的一项新指标

Abstract: Objective To study the expression of sialic acid in carcinoma of uterine cervix and its relationship with the clinical features. Methods We used biotinylated Jacalin, a special binding lectin of sialic acid, to stain sialic acid in cervical cancer cells by means of lectin-histochemical technique. The expression of sialic acid was investigated using image analysis system objectively and quantitatively. Results The expression of sialic acid in non-carcinoma cells could not be detected, the staining inte...