草酸铂致肝损伤的临床观察
Clinical Observation of Liver Function Damage Induced by L-OHP
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摘要: 目的 观察抗肿瘤药物草酸铂对肝脏的损伤情况。方法 治疗组患者给予L-OHP＋CF＋5-Fu方案化疗，对照组患者采用VP-16＋CF＋5-Fu、VP-16＋CF＋5-Fu＋DDP方案化疗，比较两组间的肝损伤情况。结果 除常见的毒性外，尚发现草酸铂致肝损伤发生率达43．3％。结论 临床在应用草酸铂方案化疗时，应常规使用护肝药物。Abstract: Objective To study the anti-tumor new medicine L-OHP(platinum oxalate) to arouse the liver function damage the possibility. Methods Ret rospective analysis of clinical materials. Results Besides the common toxicity, still discovered the L-OHP the liver function to damage 19 examples. Conclusion When L-OHP is used in the patients should be kept to the possibility of the liver function damage.
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