膀胱小细胞癌的临床病理特征分析
The Analysis of Clinical and Pathological Characteristics on Small Cell Carcinoma of the Urinary Bladder
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摘要: 目的探讨膀胱小细胞癌的临床病理特征及预后因素,提高对该疾病的认识和诊治水平。方法总结1989年1月~2005年7月国内已报道的49例膀胱小细胞癌临床资料,结合文献分析该肿瘤的组织来源、病理和免疫组织化学特征、诊治并分析各种临床病理特征与生存率相关性。结果49例膀胱小细胞癌中,男女比例4.44∶1,60岁以上男性多见。临床症状以肉眼血尿为主,肿瘤多位于膀胱侧壁,直径通常<3.0cm。病理检查见肿瘤多为混合细胞型。国内治疗以手术为主,化疗放疗其次。临床病理特征如年龄、性别、症状、肿瘤发生位置、肿瘤大小及细胞成分、免疫组化特征与其生存关系没有显著性差异。患者生存时间与膀胱切除术治疗之间也未见统计学意义(P>0.05)。结论膀胱小细胞癌是一种比较少见的高度恶性肿瘤,有独特的病理形态。血尿为主要临床表现。早期即可发生转移,预后差。确诊依靠病理检查及免疫组化,手术切除联合放疗和化疗是主要的有效治疗手段。早期发现和治疗是提高生存率和延长生存时间的关键。Abstract: Objective To study the clinical and pathological characteristics of bladder small cell carcinoma(BSC)and improve the realization,diagnosis and treatment level of this kind of diseases. Methods The tissue origination,the pathological and immunohistochemical characteristics,the diagnosis and treatment of BSC were analyzed by summarizing the related 49 clinical data and literatures,which has been reported in China from Jan 1989 to Jul 2005.The correlations of various clinicopathologic characteristics with survi...
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