弥漫性大B细胞淋巴瘤bcl-2、bcl-6、CD10蛋白表达及其在亚分类中的意义

陈愉; 赵彤; 蔡庆发; 吴炳绪; 陈美燕

doi:10.3971/j.issn.1000-8578.829

弥漫性大B细胞淋巴瘤bcl-2、bcl-6、CD10蛋白表达及其在亚分类中的意义

Expression of bcl-2,bcl-6,CD10 Protein and Their Significance in Subgroups of Diffuse Large B-cell Lymphoma

摘要

摘要: 目的探讨bcl-2、bcl-6、CD10在弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DL-BCL)中的表达及意义。方法应用免疫组织化学SP法,检测60例弥漫性大B细胞淋巴瘤标本中bcl-2、bcl-6、CD10蛋白的表达水平。结果bcl-2、bcl-6、CD10在60例弥漫性大B细胞淋巴瘤中的表达率分别为55.0%(33/60)、48.3%(29/60)、46.7%(28/60),其中CD10(+)/bcl-6(+)15例,25%;CD10(+)/bcl-6(-)13例,21.7%;CD10(-)/bcl-6(+)14例,23.3%;CD10(-)/bcl-6(-)18例,30%。CD10(+)/bcl-6(+)与CD10(-)/bcl-6(-)中bcl-2的表达差异具有统计学意义。结论bcl-2有望成为DLBCL亚分类的指标。

Abstract: Objective To investigate the expression of bcl-2,bcl-6,CD10 protein and their significance in subgroups of diffuse large B-cell lymphoma. Methods Immunohistochemistry technique(SP method) was used to assess the expression levels of bcl-2,bcl-6,CD10 protein in 60 cases of diffuse large B-cell lymphoma. Results Expression of bcl-2,bcl-6 and CD10 protein was found in 33/60(55.0%),29/60(48.3%),28/60(46.7%) cases,respectively.The CD10/bcl-6 patterns were as follows: CD10(+)/bcl-6(+) 15 cases,25%;CD10(+)/bcl-6(-)13 cases, 21. 7 %; CD10 ( - ) / bcl-6 ( + ) 14 cases, 23. 3 %;CD10( - ) / bcl-6 ( - ) 18 cases, 30 %。Expression levels of the bcl-2 protein in CD10 ( + ) / bcl-6 ( + ) pattern was higher than that in CD10 ( - ) / bcl-6 ( - ) pattern ( P = 0. 037) . Conclusion 　The bcl-2 protein may be of value to distinct subgroup s of diffuse large B-cell lymphoma.

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