Abstract: Objective To evaluate the expression of PCDGF in breast cancer and breast adenofibroma and to compare with other commonly used clinical pathological index,and then to investigate the diagnositic and targetted therapeutic purpose of PCDGF in breast cancer tissues. Methods We detected the expression of PCDGF,p53 and cerbB-2 in breast cancer tissue and the expression of PCDGF in breast adenofibroma tissue by immunohistochemical method,and took statistics to analyze the association between them. Results PCDGF expressed in most breast cancer tissues, but there was no expression in breast adenofibroma tissue almostly, and the expression of PCDGF was related with tumor's pathological category and expression of ER/ PR and p53, but there was no statistical dependence between PCDGF and cerbB-2. Conclusion 　PCDGF might be a marker in assistanting diagnosis of breast cancer. It might participate in the generation and differentiation of breast cancer cell, and could come to be an effect therapy target in breast cancer.