肝癌新生血管的形态学异常及其临床意义
Abnormality of Conf iguration of Microvessel in Hepatocellular Carcinoma
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摘要: 目的 研究肝细胞癌（HCC）新生血管的形态学异常。方法 采用免疫组化SABC法检测56例HCC组织及其相应癌旁肝组织和6例正常肝组织中CD34和Endoglin的表达,并采用透射电镜观察微血管超微结构的改变。结果 56例HCC组织中CD34和Endoglin表示的MVD值分别是127.1±5.9和64.6±11.1,而癌旁肝组织的MVD值分别是7.1±1.3和6.1±1.2。HCC组织的MVD值高于相应的癌旁肝组织,差异具有显著意义（P〈0.01）。HCC组织中微血管结构松散,通透性明显增加,可见微血管内微癌栓形成。结论 HCC组织中新生血管生成明显增加,而且这些新生的微血管在结构上是有缺陷的,这为癌细胞的转移提供了门户。Abstract: Objective To investigate the abnormality of configuration of microvessel in hepatocellular carcinoma ( HCC) . Methods Expressions of CD34 and Endoglin were studied through immunohistochemistry in fifty-six cases of HCC and their paraneoplastic liver tissue and six cases of normal liver tissue. The ultramicrost ructure of microvessel was observed using transmission elect ron microscope. Results Microvessel density (MVD) denoted by CD34 and Endoglin were 127. 1 ±5. 9 and 64. 6 ±11. 1 respectively in HCC, cont rasted with 7. 1 ±1. 3 and 6. 1 ±1. 2 in paraneoplastic liver tissue ( P < 0. 01) . The structure of microvessel was loose and the permeability increased in HCC. Microthrombi formed in the microvessel in HCC. Conclusion There was a large amount of st ructurally defect microvessel in HCC, which provided route for cancer metastasis.
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