Abstract: Objective Discussion on the value of the high-frequency color Doppler ultrasound in the differential diagnosis in the breast cancer and breast hyperplasia. Methods Retrospective analysis by opration to obtain the pathologiocal diagnose on 50 patients with breast cancer and 46 patients with breast hyperplasia(concrete tumour). Seven indexes in the tumour under the two-dimensional ultrasound morphology were observed. The blood stream signal, the artery blood stream frequency spectrum parameter and the artery frequency spect rum shape in the tumour were detected. Results 　In comparision, there are st riking differences ( P < 0. 01) in the seven indexes between the cancer group and the hyperplasia group under the two-dimensional ult rasound. The blood st ream signal in the cancer group is obviously higher than that in the hyperplasia group . The blood st ream signal in the cancer group is mainly level Ⅱor level Ⅲ,while the blood st ream signal in the hyperplasia group is mainly level 0 or level Ⅰ. In comparision, the differences between the two groups are remarkable ( P < 0. 01) . The cont raction time peak flow value (Vmax) and the resistance index ( R I) in the cancer group are higher than those in the hyperplasia group. In comparision, the differences between the two groups are remarkable ( P < 0. 05, P < 0. 01) . The differences in the artery f requency spect rum shape between the two groups are remarkable ( P < 0. 01) . Conclusion 　The high-frequency color Doppler ult rasound has the significant value in the differential diagnosis in the breast cancer and the breast hyperplasia.