Abstract: Objective 　To explore the relationship between MMP-7 expression and occurrence, biological behaviors of CC. Methods 　SP immunohistochemical staining was used to examine expression of MMP-7 among 15 cases of NM, 27 cases of Ad and 81 cases of CC paraffin-embedded specimens. Rank sum test was used to analyze the expression of MMP-7. Results 　The expression of MMP-7 from NM to Ad to CC appeared an upward tendency . The significant differences of MMP-7 expression were present any two groups ( P < 0. 01, P < 0. 01, P < 0. 01) . The expression of MMP-7 was positively correlated with lymph node metastasis ( P < 0. 05), distant metastasis ( P < 0. 01), Duke's stage . Expression in mucous group was higher than that in high differentiation group ( P < 0. 01) . The MMP-7 expression in patients aged below 60y was stronger than that in over 60y and 60y ( P < 0. 05) . Conclusion 　MMP-7 was involved in the occurrence and development of CC with high specialty, so it could be a predictive and prognostic factor of CC. Decreasing the activity of MMP-7 might be a new pathway for CC treatment .