Abstract: Objective To explore the relationship between the single nucleotide polymorphisms of XPD(G23591A、A35931C) and individual susceptibility to non-Hodgkin s lymphoma(NHL). Methods XPD G23591A and A35931C genotypes in 309 NHL cases and 305 healthy controls were detected using PCR-restriction fragment length polymorphism assay. Results No significant association between the G23591A,A35931C polymorphisms and the risk of whole NHL was shown.NHL cases were subsetted into four groups: follicular lymphoma group,diffuse large B-cell lymphoma group, T2cell lymphoma group and other B-cell lymphoma group. XPD 23591 GA + AA f requencies were 16. 3 %, 18. 0 %, 10. 5 % and 18. 4 % in each group, while 12. 5 % in cont rols, the ORs were 1. 43, 1. 58, 0. 89 and 1. 50, respectively. But no statistically significant difference was shown ( P > 0. 05) ; XPD 35931AC + CC f requencies were 15. 2 %, 15. 8 %, 18. 4 % and 12. 5 % in each group, while 11. 5 % in cont rols, the ORs were 1. 41, 1. 48, 1. 75 and 1. 12, respectively. But no statistically significant difference was shown ( P > 0. 05) . Con2 clusion 　The XPD genotypes may do not cont ribute to the risk of developing N HL in shandong area populations.