p2Ser1182ERα在乳腺癌组织中的表达及其意义
Expression of p2Ser1182ERα in Breast Cancer and Its Signif icance
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摘要: 目的 研究乳腺癌组织中丝氨酸118 磷酸化的雌激素受体α(p2Ser1182ERα) 的表达情况、与ERα、PR 表达的关系及临床价值。方法 应用免疫组织化学的方法,检测5 年前治疗的70 例原发性乳腺癌组织中p2Ser1182ERα、ERα、PR 的表达情况,进行相关分析,并用Kaplan2Meier 法分析其与三苯氧胺 ( TAM) 疗效的关系。结果 70 例ERα阳性的乳腺癌组织标本中,p2Ser1182ERα的表达与ERα的表达正相关( r = 0. 348 P = 0. 003), p2Ser1182ERα的表达与PR 的表达正相关( r = 0. 241 P = 0. 044) 。p2Ser1182 ERα阳性患者的无病生存率高于阴性患者( P = 0. 013) ; PR 阳性的患者中,p2Ser1182ERα阳性的患者的无病生存率高于阴性的患者( P = 0. 021) 。结论 p2Ser1182ERα联合PR 检测有可能为三苯氧胺疗效的评价提供一个更精确的生物指标。Abstract: Objective To study the expression of p2Ser1182ERα,ERα,PR of tissue in breast cancer by im2 munohistochemist ry and the relationship s among them. To explore the relationship between the expres2 sion of p2Ser1182ERα and the therapeutic efficacy of tamoxifen. Methods The expressions of p2Ser1182 ERα,ERα,PR in 70 breast cancer tissues were examined by immunohistochemist ry. The correlations a2 mong them were analyzed and the relationship between the expression of p2Ser1182ERαand the therapeutic efficacys of tamoxifen was analyzed by Kaplan2Meier. Results A significant correlation was found be2 tween the expression of p2Ser1182ERαand the expression of ERα (Spearman r = 0. 348, P = 0. 003) . A sig2 nificant correlation was also found between the expression of p2Ser1182ERα and the expression of PR in breast cancer (Spearman r = 0. 241 P = 0. 044) . Kaplan2Meier outcome analysis showed that patient s with positive p2Ser1182ERα had a longer disease2f ree survival than those with negative p2Ser1182ERα ( P = 0. 013) . And patient s with positive p2Ser1182ERαhad a longer disease2f ree survival than those with neg2 ative p2Ser1182 ERα ( P = 0. 021) among the cases with positive PR. Conclusion The examination of p2 Ser1182 ERαand PR maybe a precise biomarker to evaluate the efficacys of tamoxifen.
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