Abstract: Objective 　To evaluate clinical efficacy and toxicity of chemotherapy with Oxaliplatin (OXA) and Tegafur by continuous int ravenous drip in t reatment of advanced gastric cancer. Methods 　A total of 21 patients were pathologically confirmed as stage Ⅳgastric cancer missing opportunity of surgical operation. OXA 130mg/ m² was infused for two hours on d1, and Tegafur 600mg/ m² was continuous infused by pump on d1 to d5. One cycle comprised 3～4 weeks, and the efficacy was evaluated after 2 cycles and 4 weeks. Results 　In 21 patients, CR was seen in 0 patient s and PR in 12 patient s (57. 1 %) and NC in 6 patients (28. 6 %) and PD in 3 patients (14. 3 %), with total response rate of 57. 1 %. The median remission period was 4. 6 months, the median survival period was 8. 3 months. The CBR was 85. 7 %. The toxicity was mild neural toxicity and gast rointestinal tract toxicity. Conclusion 　OXA combined with Tegafur by pump for treatment of advanced gastric cancer has relatively high response rate, and the toxicity can be well tolerated.