血清高半胱氨酸含量与恶性肿瘤的关系

The Relationship between Serum Homocysteine and Malignant Tumors

摘要: 目的探讨血清高半胱氨酸水平与恶性肿瘤的关系。方法采用A/CDiagnosticsHomocysteineEnzymaticMicrotiterPlateAbsorbanceAssay测定249名恶性肿瘤患者和215名健康对照的血清高半胱氨酸水平。结果恶性肿瘤患者血清高半胱氨酸几何均数为118.48μM/L(95%CI:116.40～120.56),对照组为11.20μM/L(95%CI:8.16～14.24),两组差异非常显著(t=27.307,P=0.000)。不同部位和不同组织类型恶性肿瘤之间没有明显差异(P<0.05)。经非条件Logistic回归分析,血清高半胱氨酸可增加恶性肿瘤危险性13.082倍(95%CI:7.544～22.685)。其诊断的灵敏度和特异度分别为91.16%和95.35%。结论在排除心血管疾病和糖尿病后,血清高半胱氨酸可作为恶性肿瘤的标志物

Abstract: Objective To assess the relationship serum homocysteine and malignancy. Methods The content of serum homocysteine was measured in the 249 malignant tumor cases and 215 health controls by A/C Diagnostics Homocysteine Enzymatic Microtiter Plate Absorbance Assay. Results The geometric mean of serum Hcy is 118.48μM/L(95%CI: 116.40~ 120.56)for cases and 11.20μM/L (95%CI: 8.16~ 14.24) for controls. A remarkable difference was obtained between cases and controls(t= 27.307,P= 0.000). The difference was not obtained...